TRPM4 is widely expressed in several tissues and is involved in a variety of physiological processes, including modulation of immune cells activity, such as T-cells (Launay et al., 2004), mast cells (Shimizu et al., 2009) and dendritic cells (Barbet et al., 2010), insulin secretion by pancreatic β cells (Cheng et al., 2007), mechano-transduction in cerebral arteries (Vennekens and Nilius, 2007), and Ca2+ signaling in cancer (Sozucan et al., 2015; Ceylan et al., 2016; Sagredo et al., 2017). Here, INS is linked to cancer.