Recent studies have linked genetic variants of TRPM4 gene to progressive familial heart block type 1 (PFHB1) (Kruse et al., 2009; Daumy et al., 2016), isolated cardiac conduction disease (ICCD) (Liu et al., 2010), atrio-ventricular block (AVB) (Stallmeyer et al., 2012; Syam et al., 2016), right bundle branch block (RBBB) (Stallmeyer et al., 2012) and Brugada syndrome (BrS) (Liu et al., 2013; Gualandi et al., 2017). This evidence concerns the gene TRPM4 and Brugada syndrome.