In addition, Wnt-1-induced secreted protein (WISP-1), as an important downstream target gene of Wnt1/β-catenin signaling, was reported to prevent cancer from P53-mediated apoptosis and inhibit the mitochondrial release of cytochrome c and elevate the expression of anti-apoptotic protein Bcl-XL31. The gene discussed is CCN4; the disease is cancer.