ALPI and colitis: This scenario is coherent with data in ALPI‐deficient mice, which did not spontaneously develop intestinal inflammation, but displayed markedly increased susceptibility to dextran sodium sulphate‐induced colitis (Ramasamy et al, 2011) as well as increased gut permeability (Rentea et al, 2012) and enhanced LPS translocation when subjected to direct or indirect gut injury (Kaliannan et al, 2013).