FLNB is important for fetal skeletal development and FLNB mutations are associated with atelosteogenesis I, Larsen syndrome, and spondylocarpotarsal synostosis syndrome, a disease of ectopic ossification that causes inappropriate fusion of the bones of the vertebrae, wrists, and ankles. The gene discussed is FLNB; the disease is Spondylocarpotarsal synostosis.