The notable pathways included the pathways in cancer, MAPK signaling pathway, the cGMP-PKG signaling pathway, the cAMP signaling pathway, endocytosis, the neurotrophin signaling pathway, the PI3K-Akt signaling pathway, regulation of the actin cytoskeleton, focal adhesion, axon guidance, proteoglycans in cancer, the longevity-regulating pathway, the Ras signaling pathway, HTL-I infection, the phospholipase D signaling pathway, metabolic pathways, the Rap1 signaling pathway, the Hippo signaling pathway, and the insulin signaling pathway. Here, INS is linked to cancer.