Care et al. was the first to demonstrate that among the 3 major direct targets for miR-133 (RhoA a GDP-GTP exchange protein), Cdc42 (signal transduction kinase) and Nelf-A/WHSC2 (nuclear factor), RhoA and Cdc42 have a distinct role in regulating cardiac hypertrophy [144]. Here, NELFA is linked to cardiac hypertrophy.