In SSc patients, anti-CXCR3 and anti-CXCR4 ab levels were weakly and negatively correlated with the corresponding ages at assessment (r = −0.2, p ≤ 0.001; and r = −0.2, p ≤ 0.001, respectively) and with the age at SSc diagnosis (r = −0.24, p ≤ 0.001; and r = −0.27, p ≤ 0.001, respectively), but not with disease duration (data not shown). This evidence concerns the gene CXCR4 and systemic sclerosis.