The cross-sectional analyses showed that the subgroup of patients with confirmed SSc-ILD and FVC < 70% had significantly lower median anti-CXCR3 and anti-CXCR4 ab levels than those with FVC ≥ 70% (2.9 U vs. 4.8 U, p ≤ 0.01, n = 82; and 2.8 U vs. 5.0 U, p ≤ 0.05, n = 78, respectively). Here, CXCR4 is linked to systemic sclerosis.