There is also increasing evidence that oncogenes and/or tumour-suppressor genes can reprogramme tumour cell metabolism including the direct regulation of the amino acid transporter, solute carrier family 7 member 5 (SLC7A5), by the oncogene MYC [4, 5] and the regulation of expression of the glutamine transporter, SLC1A5, by the tumour suppressor retinoblastoma (Rb) [6]. This evidence concerns the gene RB1 and neoplasm.