Previous studies demonstrated that serum levels of TNF-α, IL-6, IL-1β, and IL-18 are significantly elevated in patients with AOSD and that blocking these proinflammatory cytokines with antibodies or recombinant soluble receptor dramatically alleviated the disease severity in patients with AOSD [11, 12, 14, 18, 40, 43, 49, 50]. The gene discussed is TNF; the disease is adult-onset Still disease.