Using this criterion, we found 5 additional suggestive associations, namely TGFB2 (1q41), HHIP (4q31), and RIN3 (14q32.12) with severe COPD, and HHIP (4q31) with %LAA-950 and Perc15 (Additional file 1: Table S3). The gene discussed is TGFB2; the disease is chronic obstructive pulmonary disease.