MAP3K5 and neoplasm: This gene is a tumour suppressor, and its inactivation is closely associated with tumours in the reproductive system.12, 13, 14, 15 The C2 domain of the DAB2IP protein reportedly interacts with the apoptosis signal‐regulating kinase 1 (ASK1) protein; therefore, the DAB2IP protein is also known as ASK1‐interacting protein (AIP).12, 14, 16, 18 Di Minin et al showed that when the TNF‐α‐mediated activation of the ASK1/JNK pathway was inhibited by NFκB, a mutant p53 was activated.