As already reported, the NF‐κB signalling pathway has been confirmed to function as not only an important player in cancer development23 but also a key regulator of the EMT‐related transcription factors.24 Mechanistically, we first revealed that CRYAB silencing noticeably decreased the protein level of p‐NF‐κB p65 in MKN45 cells, suggesting the inactivation of NF‐κB pathway. This evidence concerns the gene NFKB1 and cancer.