CD4 and Splenomegaly: Interestingly, even if similar degrees of splenomegaly (S4 Table) that correlated with similar numbers of CD3+ T-cells in the spleen (Fig 3A) were detected, it remains that the number as well as the percentage of CD4+CD25+ T-cells among human splenocytes were higher in WT than in ΔPBM hu-mice (Fig 3B–3D).