Additionally, the loci on chromosome 1 contains a cohort of biologically interesting genes (Cflar, Clk1, Ndfufb3, Nif3l1, Bzw1, Ppil3, Casp8, Fam126b) recently reported in another association mapping study to be predictive markers in cellular toxicity to triptolide, an anti-inflammatory and immunosuppressive compound commonly used in traditional Chinese medicine to treat several immune complex diseases such as rheumatoid arthritis and systemic lupus erythematous [59, 60]. This evidence concerns the gene CASP8 and rheumatoid arthritis.