K11777 is also effective in vitro and in vivo in a number of parasites which all have a central cathepsin B or L linked to pathogenicity including schistosomiasis [32], amebiasis [33], Tritrichomonas foetus [34], Leishmania tropica [35], hookworm [36], and Cryptosporidium parvum [37]. Here, CTSB is linked to amebiasis.