CELF1 and cataract: In mouse, all three Celf1 homozygous deletion mouse genotypes–Celf1cKO/cKO, Celf1cKO/lacZKI and Celf1lacZKI/lacZKI–exhibit severe lens defects including cataracts at early postnatal (P) stages (Fig 1I–1K’; S6A and S6B’ Fig).