Similar to human MMs, the tumors developed by the Nf2 (+/−) mice exhibited frequent homologous deletions of the Cdkn2a/Arf locus and adjacent Cdkn2b tumor-suppressor gene, as well as reciprocal inactivation of Tp53 in a subset of tumors that retained the Arf locus [51]. Here, CDKN2A is linked to neoplasm.