Curcumin has also shown cancer-preventive properties through the modulation of COX-2, NF-κB, 5-lipoxygenase (5-LOX), STAT3, C-reactive protein (CRP), prostaglandin E2 (PGE2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-β (TGF-β), and several pro-inflammatory and apoptotic cytokines [39]. This evidence concerns the gene STAT3 and cancer.