It was found that caspase-3 activity in HCT116 colon cancer cells pre-treated with BAY 11-7082 and treated with 6.25 mM, 12.5 mM, 25 mM, and 50 mM concentrations of NaB was significantly higher than cells that were not pre-treated with BAY 11-7082 and treated with the same respective concentrations of NaB. The gene discussed is CASP3; the disease is malignant colon neoplasm.