Despite coming from different patients and different lineages, the CF P. aeruginosa genomes studied here had similar mutational patterns affecting the same genes (e.g., oprD, mexAB, mutL, and mutS), suggesting a common selective pressure (Table 3,  to , 5; see also Table S3 and S4) (Fig. 3). Here, OPRD1 is linked to cystic fibrosis.