Therefore, SD and HFSD offspring may have been partially protected from reduced insulin sensitivity through altered regulation of leptin and its downstream target, Igfbp2. In offspring exposed to maternal undernutrition, we reported increased circulating leptin concentrations, in the absence of altered hepatic Igfbp2 expression, which may indicate hepatic leptin resistance (41). Here, IGFBP2 is linked to Salla disease.