B2M and cancer: In many types of tumors, cancer cells undertake considerable efforts to keep the host’s immune system at bay; this involves both the tumor cells themselves, which express immunosuppressive surface proteins such as PDL1, B7, or human leukocyte antigen (HLA) G, less MHC1 or its compound β-2 microglobulin (B2M), as well the microenvironment of the tumors, which is influenced and manipulated by the tumor cells (8).