CD274 and classic Hodgkin lymphoma: An important feature of cHL [and primary mediastinal B-cell lymphoma (PMBCL)] is gain of chromosome 9p24 (Figure 2A), which leads to an overexpression of PDL1 (25, 26) that can also be shown in situ (27, 28), and seems to be of probable prognostic importance in patients treated with standard treatment regimens (25) and offers the opportunity to be specifically targeted, resulting in unprecedented response rates in otherwise hopeless cases of multiple-relapsing cHL (29).