The function of CD58 in cHL is two-faced: on the one hand, it is necessary for HRS cells to communicate with CD4-positive T-cells (35), on the other hand, loss of CD58 expression due to mutations can facilitate immune escape, especially in advanced disease, when HRS cells become less dependent on the surrounding microenvironment (36, 37). This evidence concerns the gene CD58 and classic Hodgkin lymphoma.