Taking in account that, as stated above, an opposite abnormal repartition of the mentioned monocyte subsets, with increased fractions of CD16+ monocytes, has been described in inflammatory and autoimmune conditions [56, 57], infections [54, 55, 57, 63], and cancer [58, 59], the selective depletion of CD14+CD16+ monocytes in the PB would probably be important for the differential diagnosis between MDS and non-MDS cytopenias. The gene discussed is CD14; the disease is infection.