In our study population, we found no significant association of NTDs, EOPE, LOPE, or nIUGR with high-risk 677TT or 1298CC placental genotypes, although there was a tendency to increased MTHFR 677TT in pregnancies affected by PE or IUGR as a whole (OR 2.53, p = 0.048). Here, MTHFR is linked to fetal growth restriction.