mRNA level of p16(INK4a) gene, as a marker of cellular senescence, increased significantly in livers of rats in HF group when compared to the C group, while the mRNA level of p21(Cip1), another inhibitor of cyclin-dependent kinase, was significantly lower in HF group than in C group (Fig. 3a). Here, CDKN2A is linked to hydrops fetalis.