Exploring the recently discovered gene variants of susceptibility to the condition, like in Mdm2 (Mouse double minute 2) and BCL11 (B-cell lymphoma), and those incriminated specifically to have no interaction with drinking and smoking, in HLA (human leukocyte antigen) region 6p21, FADS1 gene (fatty acid desaturase 1) and tumor suppressor TBX5 (T-box 5) genes, should be analyzed to quantify the inherited risk to develop LSCC in nondrinkers and nonsmokers, and provide a rational ground to anticipate and prevent the disease in the population [44–46]. Here, FADS1 is linked to B-cell non-Hodgkin lymphoma.