Overexpression of SIRT-1 ameliorates high fat diet induced hepatic steatosis with enhanced energy expenditure and improved glucose tolerance (Pfluger et al., 2008), whereas hepatic deletion of SIRT-1 exhibit a significantly increased triglyceride accumulation in hepatocytes (Purushotham et al., 2009). Here, SIRT1 is linked to Hepatic steatosis.