Selective blockade of the pro-inflammatory cytokine, Interleukin-1β (IL-1β), has been shown to reduce seizures in in vivo models of epilepsy (Ravizza et al., 2008; Vezzani et al., 2009), while in an epileptogenesis-resistant animal, the Amazon rodent, Proechimys, no acute brain inflammatory response was found following experimentally-induced status epilepticus (Scorza et al., 2017). Here, IL1B is linked to status epilepticus.