Interestingly, MWM acquisition correlated with the previously studied microglial CD68 changes in the DG but not with the DG Aβ plaque load (Hoeijmakers et al., 2017), indicating that, similar to the phenotype at 4 months, the APP/PS1-induced neuroinflammatory changes might be associated with the emergence of the cognitive deficits (Dinel et al., 2011; Czerniawski and Guzowski, 2014; Guo et al., 2015; Fonken et al., 2016). This evidence concerns the gene APP and Cognitive impairment.