The first cognitive deficits have been reported to arise in APP/PS1 mice after approximately 6 months of age (Jankowsky et al., 2005; Zhang et al., 2012; Edwards et al., 2014; Guo et al., 2015) and we therefore addressed whether ES would have aggravated cognitive performance at 9 months, when the deficits should have been firmly established. The gene discussed is APP; the disease is Cognitive impairment.