An increase in among others DCX+ cell numbers has also been reported in 3-month-old APP/PS1 mice, as well as in other AD-related transgenic lines, in particular during the earlier pathological stages when no or little plaque formation has developed yet (Wen et al., 2002; Krezymon et al., 2013; Unger et al., 2016). Here, APP is linked to Alzheimer disease.