Next to cognitive deficits, APP/PS1 mice have been described to exhibit reduced AHN around the age of 9–10 months (Taniuchi et al., 2007; Verret et al., 2007; Niidome et al., 2008; Demars et al., 2010; Hu et al., 2010; Hamilton and Holscher, 2012), although there are expectations as well (Taniuchi et al., 2007; Hamilton and Holscher, 2012; Unger et al., 2016). This evidence concerns the gene APP and Cognitive impairment.