APP and neurodegenerative disease: The presence of genes for neurodegenerative diseases that have human orthologs, such as amyloid precursor protein (APP), tau, and UNC13A, as well as the wide array of transgenic strains, constitute the formidable advantage of using C. elegans to study neurodegeneration (Link, 2006; Wolozin et al., 2011; Alexander et al., 2014).