AEs associated with VEGF pathway inhibition, and other any-grade AEs of special interest, included (for nintedanib vs. sorafenib) specific liver-related investigations (24.2% vs. 25.8%), bleeding (29.0% vs. 22.6%), rash (21.0% vs. 38.7%), hypertension (14.5% vs. 9.7%), cutaneous adverse reactions (4.8% vs. 19.4%), thromboembolic events (1.6% vs. 12.9%) and gastrointestinal (GI) perforation (0% vs. 3.2%). The gene discussed is VEGFA; the disease is hypertensive disorder.