CDH1 and malignant colon neoplasm: It is noteworthy that a density-dependent, EMT-like response is not only manifested by 4T1 cells: a similar process has been reported in a variety of other cell lines (e.g., SW480 colon cancer cells; MCF10A breast cells), all of which undergo major phenotypic, EMT-like changes, including low levels of E-cadherin, when plated sparsely45,46.