In the absence of Hh agonist, SMO was mostly undetected in primary cilia of NHK and ADPKD cells, but following treatment with SAG, a SMO agonist, NHK and ADPKD cells showed similar ciliary enrichment of SMO (Fig. 4B), suggesting similar Hh signaling levels. The gene discussed is SMO; the disease is autosomal dominant polycystic kidney disease.