As a second protein we chose MDH2 exhibiting the deviant behavior amongst the TCA proteins, as it was upregulated statistically significantly both in PC vs BPH (p < 0.001; Mann–Whitney test) and further upregulated in CRPC vs PC (p < 0.05; Mann–Whitney test) (Fig. 5b). The gene discussed is MDH2; the disease is pachyonychia congenita.