As a representative of the most common alteration pattern we chose aconitase 2 (ACO2) which showed statistically highly significant (p < 0.001, Mann–Whitney test) upregulation of the protein in PC vs BPH, as well as statistically highly significant (p < 0.001, Mann–Whitney test) downregulation in CRPC vs PC (Fig. 5b). Here, ACO2 is linked to benign prostatic hyperplasia.