MYC translocation frequencies more similar to those we observed have been detected in newly diagnosed MM patients using both FISH—15% [79 of 529; 95% CI (12%-18%)]33 and 23% [62 of 274; 95% CI (18%-28%)]34,35—and a capture-based next-generation sequencing approach similar to that presented here—20% [21 of 104; 95% CI (13%-28%)]14. Here, MYC is linked to Miyoshi myopathy.