Quantitative analysis of the PL-RCA signal strength by manually counting the percentages of those PL-RCA-positive cells per 500 DAPI-positive cells demonstrated a significant increase in the PL-RCA signals of co-localization of NSUN1 and RNA-pol-II CRD-S2P in the 5-AZA-resistant AML/MDS bone marrow specimens compared to the 5-AZA-sensitive AML/MDS bone marrow specimens. This evidence concerns the gene NOP2 and acute myeloid leukemia.