Immunohistochemical analysis demonstrated lower expression levels of CD34, hnRNPK, NSUN1 and BRD4 in the normal bone marrow cells, and significantly increased expression levels of these proteins in the bone marrow cells of the MDS/RCMD and AML cases, and the increased expression of these proteins was correlated with the disease progression in these MDS/AML cases (Fig. 10c). The gene discussed is BRD4; the disease is acute myeloid leukemia.