These data demonstrate that compared to ASLCs, ARLCs had increased levels of RNA:m5C, RCMTs and hnRNPK with preferential binding to cytosine-methylated RNA, suggesting that RNA:m5C, RCMTs and hnRNPK may be involved in 5-AZA response/resistance in leukaemia cells. Here, HNRNPK is linked to leukemia.