RNase digestion-coupled immunoprecipitation (IP) and co-immunoprecipitation (co-IP) demonstrated RNA-independent, direct binding of hnRNPK to a subset of RCTMs, namely, DNMT2 and NSUN3, in OCI-M2 leukaemia cells (Fig. 2a). This evidence concerns the gene TRDMT1 and leukemia.