RNase digestion-coupled IP and co-IP revealed a direct interaction between hnRNPK and CDK9/P-TEFb and indirect interactions between hnRNPK and CDK7/TFIIH as well as RNA-pol-II CTD-S2P in the OCI-M2 leukaemia cells (Fig. 5b). The gene discussed is CDK7; the disease is leukemia.