HNRNPK and leukemia: Based on all the above-described data, we hypothesized a working model of the hnRNPK/RCMT-mediated lineage-associated, 5-AZA-sensitive active chromatin structure at nascent RNA in leukaemia cells and a novel 5-AZA action mechanism through disruption of the hnRNPK-associated active chromatin structure (Fig. 5f).