To our surprise, the markedly increased interactions between hnRNPK and CTD-S2P as well as GATA1 in the 5-AZA-resistant M2AR leukaemia cells were still highly sensitive to 5-AZA, and 5-AZA rapidly disrupted these interactions within 10 min in these cells (Fig. 6b), suggesting an hnRNPK-independent mechanism for 5-AZA-resistance. Here, HNRNPK is linked to leukemia.