The indirect contribution of NF-κB is attributable to the fact that this transcription factor contributes to the regulation of most (but not all) classical hallmarks of cancer, as defined by the Hanahan and Weinberg review: sustained proliferative signaling, resistance to cell death, replicative immortality, induction of angiogenesis, activation of invasion and metastasis, and reprogramming of energy metabolism [41]. This evidence concerns the gene NFKB1 and cancer.