A complex polysaccharide (a rhamnogalactouronan, termed GR-MD-02) has emerged as a relatively potent Gal-3 antagonist with considerable promise in preclinical animal models and clinical trials against non-alcoholic steatohepatitis (NASH) and toxic cirrhosis, demonstrating action at multiple pathophysiological processes [127,128,129,130]. The gene discussed is LGALS3; the disease is metabolic dysfunction-associated steatohepatitis.