LGALS1 and neoplasm: Gal-1 potently induces apoptosis in activated T-cell resulting in an overall Th2 cytokine profile (e.g., Interleukin (IL)-4, -5, and -13) over a tumoricidal Th1 cytokine profile (e.g., INFγ, IL-2 and TGF-β) blocking immune effector functions while promoting IL-10-producing regulatory T cells to create an immune privileged site at the tumor [139,181].