In this regard, conditioned media from gastric cancer cells induces expression of Gal-1 and the EMT marker α-SMA in normal fibroblasts, thus causing normal fibroblast transformation into mesenchymal cancer-associated fibroblasts via a transforming growth factor-β (TGF-β) dependent mechanism and the progression of gastric tumors [96]. Here, LGALS1 is linked to gastric neoplasm.