Another designed peptide anginex (33 amino acid residues) that targets Gal-1 (Kd ~ 90 × 10−9 M) [108] displays multimodal activities in terms of inhibiting tumor endothelial cell (EC) adhesion, migration and proliferation [132,133] and promoting leukocyte infiltration into tumors [134,135] leading to tumor growth inhibition in mouse models [136,137,138]. Here, LGALS1 is linked to neoplasm.