LEF1 and hepatocellular carcinoma: E.g., Bacigalupo et al. [92] noted that in hepatocellular carcinoma (HCC) cell line HepG2 Gal-1-associated EMT was mediated through β-catenin nuclear translocation, TCF4/LEF1 transcription activity and increased cyclin D1 and c-Myc gene expression, implying the involvement of the Wnt pathway.