In prostate cancer VEGF promotes angiogenesis by binding VEGF-R2 (Flk-1) on the vascular endothelial lining to promote proliferation and vascular permeability, then organization of nascent capillary tubes into the tumor microenvironment via VEGF-R1 (Flt-1) [57,58,59]. This evidence concerns the gene VEGFA and Familial prostate cancer.