A recent study by Yang et al. demonstrated that loss of pTEN in human prostate cancer cells promotes activation of an AKT-runt related transcription factor 2 (Runx2) signaling axis that induces expression of steroidogenesis genes CYP11A1, CYP17A1, and intratumoral androgen synthesis [44]. Here, AKT1 is linked to Familial prostate cancer.