TGFB1 and neoplasm: Transforming Growth Factor-β (TGF-β): TGF-β is an intriguing cytokine with bifunctional roles in the regulation of the normal prostate growth, balancing the signaling interactions within the microenvironment, acting as tumor suppressor via the apoptosis induction in the early stages of tumorigenesis and switching to a metastasis promoter via effects on epithelial-mesenchymal transition (EMT) during tumor progression to metastasis.