In addition, a highly sensitive high-throughput imaging-based platform with 12,800 small molecules identified homoharringtonine (HHT), an FDA-approved drug that may be used to treat chronic myeloid leukemia (CML), as a synthetic lethality partner in VHL-loss tumors [111]. This evidence concerns the gene VHL and chronic myelogenous leukemia, BCR-ABL1 positive.