TSC2 and non-small cell lung carcinoma: Phosphorylation of at least two of the three further known Akt target proteins Proline-rich AKT1 substrate 1 (PRAS40), tuberous sclerosis 2 (TSC2) and TBC1 Domain Family Member 4 (TBC1D4) in non-small cell lung cancer cell lines also required Akt1-phosphorylation at T308 for their activation [129].