AKT1 and malignant glioma: In contrast, down-regulation of specific miRNAs, that limit PI3K/Akt pathway activation e.g., miR-31, miR-126, miR-203, miR-302, have similarly been associated with up-regulated activity of Akt, increased tumor cell proliferation and radioresistance in undifferentiated thyroid carcinoma, lung adenocarcinoma, nasopharyngeal carcinoma and malignant glioma, or breast cancer, respectively [111,112,113,114,115].