GH1 and Myalgia: A recent randomized, open-label, clinical trial including 32 adults receiving GH therapy for at least one year showed that although increasing GH dose to achieve IGF-I levels between 1 and 2 Standard Deviation Score (SDS) improved waist circumference and the overall better feeling, safety was not guaranteed with the demonstrated effect on HDL cholesterol in men, and reported myalgia [56].