A recent study, including 426 patients with nonfunctioning pituitary adenomas, with 4599 patient-years of follow-up, of whom 207 had used GH therapy and 219 had not received GH, showed a reduced overall mortality in GH-treated patients compared with the general population and found that death due to malignancy was not increased in GH-treated patients [79]. The gene discussed is GH1; the disease is cancer.