It was shown that 14-3-3β, a scaffold protein, the expression of which correlates with malignance grade in astrocytomas, negatively regulated senescence in the GBM A172 cells through the ERK-SKP2-p27 (extracellular signal regulated kinase-S-phase kinase-associated protein 2-p27) pathway [67]. Here, MAPK1 is linked to glioblastoma.