Another ERK-related pathway, which can be modulated in senescent GBM cells was reported by Liu et al. who showed that berberine, an isoquinoline alkaloid, induced senescence in downregulated EFGR-MEK-ERK (epidermal growth factor receptor-mitogen-activated protein kinase kinase-ERK) signaling pathway [68]. Here, MAPK1 is linked to glioblastoma.