CDK1 and Ataxia-telangiectasia: This effect is mediated by the activation of the ATM/ATR-Chk1/2 (ataxia telangiectasia mutated/ataxia telangiectasia and Rad3-related-checkpoint kinase 1/2) axis, subsequent activation of the Wee1 kinase, Cdk1 (cyclin dependent kinase 1) activation and inhibition of CDC25A (cell division cycle 25A) [33,34].