These mutations interrupt uORFs associated with well-studied oncogenes and tumor suppressors. MYC and BCL2 are the two genes associated with the greatest recurrence of uORF interruptions, and we identify recurrent mutation of positively scored uORFs associated with PTEN, TP53, ERCC1 and MSH5. An annotation of Supplemental Table S11 is provided indicating somatic variants that affect uORFs associated with COSMIC cancer genes, as well as recurrent somatic variants affecting uORFs that are recurrent across patient samples. Here, PTEN is linked to cancer.