Notably, however, selective pressure for 5q loss might also be conferred by co-operative effects because of loss of multiple genes, including KIBRA. Indeed, it has been suggested that loss of multiple DNA damage response and cell cycle genes upon 5q deletion may promote genomic instability and tumor progression (Curtis et al., 2012, Weigman et al., 2012). This evidence concerns the gene WWC1 and neoplasm.