LATS1 and neoplasm: KIBRA encodes a multi-domain scaffold protein (Kremerskothen et al., 2003) acting upstream of the Hippo tumor suppressor pathway, interacting with MERLIN and LATS1/2 to inhibit the oncogenic transcriptional co-activators YAP/TAZ (Baumgartner et al., 2010, Genevet et al., 2010, Yu et al., 2010).