IDH1 and anaplastic oligodendroglioma: To investigate the changes in redox-active pathways induced by the IDH1 R132H mutation, we utilized a human anaplastic oligodendroglioma (HOG) cell line engineered to express either wild-type (WT) or mutant (R132H) IDH1 (Reitman et al., 2011) (Figure S1A).