Model 1: adjusted for age, gender, race/skin color; Model 2: model 1 plus hypertension, diabetes mellitus, dyslipidemia, smoking, BMI, HDL-cholesterol, triglycerides, glomerular filtration rate by CKD-Epi (Chronic Kidney Disease Epidemiology Collaboration), and C-reactive protein. The gene discussed is CRP; the disease is metabolic syndrome.