As increased glomerular hypertrophy and podocyte loss are characteristic of FSGS, we analyzed the effect of CCX872 treatment on glomerular size and podocyte density by staining kidney sections from 5/6 nephrectomized mice with an antibody specific for the podocyte marker Wilms tumor protein 1 (WT-1) (Fig 6). This evidence concerns the gene WT1 and focal segmental glomerulosclerosis.