Knowing that miR-34a had been shown to target the transcript for SIRT1 in human colon cancer cells [148], the authors hypothesized that the previously reported up-regulation of miR-34c in AD may lead to decreased production of SIRT1 in the hippocampus, and thus diminished performance in memory-based tasks due to the fact that SIRT1 production in the hippocampus had been correlated with memory formation and learning in mice. This evidence concerns the gene SIRT1 and colonic neoplasm.