PDLIM7 and in situ carcinoma: While there is no clear explanation for the lack of LMP1 detection in pre-neoplastic nasopharyngeal tissue but consistent detection in preinvasive lesions (dysplastic and carcinoma in situ), culture systems that retain the diversity of cell types representative of primary tissue may help to stratify the expression of LMP1 in different cell types upon de novo infection and possibly during the early events of oncogenesis [22,26,27,66,67].