These findings from LMP1 strain variant studies in NPC and in other EBV-associated diseases are consistent with a model in which EBV infection is dynamically transmitted between the oropharynx and peripheral sites, and that specific isolates can also be compartmentalized within local and peripheral sites at least for the selection of LMP1 strains [81,87]. The gene discussed is PDLIM7; the disease is Epstein-Barr virus infection.